TRIPping Constructivism

Tripping the HCN Breaker

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate neuronal excitability, pacemaking, dendritic integration, and homeostatic plasticity and are culprits in aberrant neuronal activity in certain epilepsies. In this issue of Neuron two manuscripts (Santoro et al. and Zolles et al.) report that HCN channel gating and expression are controlled by Trip8b (Pex5R) but with a b...

Tripping Over TRPC

About the cover: Colocalization of P2X4 using Anti-P2X4 antibody (#APR-002) (red) and P2X3 (green) subunits in the distal population of GPN neurons in situ by confocal immunofluorescence. Special Acknowledgement to Professor Colin A. Nurse from the Department of Biology McMaster University, Ontario Canada for allowing Alomone Labs to use part of a published figure as this Modulator's cover page...

Why Do GFCIs Keep Tripping?

As well known, ground fault circuit interrupters (GFCIs) are used to protect people from electric shock. Recently, a manufacturer installed variable speesd drives (VSDs) in all their products. After receiving feedback from their customers, they realized that their products would only work when powered through some GFCI outlets but not work when powered through others. To investigate this proble...

Info-computational Constructivism

Context: At present we lack both a common understanding of the process of cognition in living organisms (with or without a nervous system and brain) and the details of the construction of knowledge in embodied, embedded cognizing agents in general, including future artifactual intelligent agents under development, such as cognitive robots and softbots. The info-computational approach is focused...

Interpreting Legal Constructivism